A Connected Approach To High Throughput Screening
In recent years Compound Managers have seen a significant increase in the size of pharmaceutical compound collections from hundreds of thousands to millions. Today, many companies can screen millions of compounds through hundreds of targets per year with each campaign lasting only a matter of weeks. Read the PDF below, it illustrates compounds can be stored in a ‘Wet’ or ‘Dry’ format. Wet or dry refers to storing compounds as solids or dissolved in solvent such as DMSO. DMSO is very hygroscopic, so, when exposed to the atmosphere, it adsorbs moisture and will continue to do so and as a result of this many organisations opt for a temperature-controlled compound management solution.
A connected approach utilising the strengths of multiple vendors to achieve a seamless automated workflow can lead to improved timelines for screening and hit identification through to lead optimization and candidate selection while protecting the integrity of the compound collection in an automated storage and retrieval system.
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